[Todos] RECORDATORIO SEMINARIO IFLP/DEPARTAMENTO DE FÍSICA

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> -------------------------------------------------------------------------------------------- 
> 
> SEMINARIOS  DEL IFLP Y DEL DEPARTAMENTO 
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> MARTES 10 DE MAYO A LAS 11HS. 
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> AULA CHICA 
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> TÍTULO: BIO-IDENTITY OF PROTEIN-COATED SPIONS EVALUATED IN CELLS AND 
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> _IN VIVOV_BY THE _C. ELEGANS _MODEL 
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>   
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> EXPONE: ANNA ROIG. INSTITUT DE CIÈNCIA DE MATERIALS DE BARCELONA (ICMAB). 
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> CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), CAMPUS DE LA UAB, SPAIN
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>  
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> RESUMEN: _Superparamagnetic iron oxide nanoparticles (SPIONs) are already demonstrating huge potential in nanomedicine. SPIONs are investigated as MRI contrast agents, in hyperthermia treatment, for drug delivery, targeting therapies, biosensing and magnetic separation. The stability of SPIONs in complex biological environments remains a challenge and simple surface coatings to stabilize the nanoparticlesenhancing at the same time their therapeutical effect are currently being investigated._ 
> 
> _The talk will include a brief introduction to some synthetic approaches used in my group.[1] _ 
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> _Then I will present that bovine serum albumin (BSA) can be used to preform a protein corona on the nanoparticles surface to stabilize them in biological media. Cellular uptake, intracellular particle distribution and cytotoxicity of the newly acquired bio-identity of the protein coated SPIONswill be addressed.[2]_ 
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> _The in vivo physiological response to the nanoparticles evaluated on the Caenorhabditis elegans model will also be presented.[3] Finally, I will demonstrate the application of magnetic nanoparticles and nanocapsules to promote angiogenesis as a brain neurorepair therapy after stroke. [4] [5]_ 
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> [1] Rapid synthesis of water-dispersable SPIONs by microwave assisted route for safe labeling of 
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> endothelial progenitor cells, Carenza et al. _Acta-Biomaterialia_10 (2014) 3775 
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> [2] Bio-identityandfate of albuminpre-coated SPIONs evaluated in cells in vitro and in vivo with the C. 
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> elegans model, Si-Ming Yu, et al. submitted 
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> [3] Protective effects of Bovine Serum Albumin on superparamagnetic iron oxide nanoparticles evaluated 
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> in the nematode Caenorhabditis elegans Gonzalez-Moragas et al., ACS Biomaterials Science & 
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> Engineering. 1, 11 (2015) 1129 
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> [4] In vitro Angiogenic Performance and in vivo Brain Targeting of Magnetized Endothelial Progenitor Cells 
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> for Neurorepair Therapies, Carenza et alNanomedicine: NBM 10, 1 (2014) 225 
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> [5]Encapsulation of VEGF165 in magnetic PLGA nanocapsules for potential local delivery and bioactivity 
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> into human brain endothelial cells, Carenza et al, J. Mater. Chem. B, 2015,

 
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