[Todos] SEMINARIO IFLP/DEPARTAMENTO DE FÍSICA

[tierno]

ESTIMADOS: 

AGRADECEMOS LA DIFUSIÓN DEL ANUNCIO DEL SEMINARIO DEL CICLO DE COLOQUIOS
Y SEMINARIOS QUE SE ORGANIZAN EN EL INSTITUTO DE FÍSICA LA PLATA/
DEPARTAMENTO DE FÍSICA. 

SALUDOS,  
ATTE. 

ADMINISTRACIÓN IFLP 

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SEMINARIOS  DEL IFLP Y DEL DEPARTAMENTO 

MARTES 10 DE MAYO A LAS 11HS. 

AULA CHICA 

 TÍTULO: BIO-IDENTITY OF PROTEIN-COATED SPIONS EVALUATED IN CELLS AND 

_IN VIVOV_BY THE _C. ELEGANS _MODEL 

  

EXPONE: ANNA ROIG. INSTITUT DE CIÈNCIA DE MATERIALS DE BARCELONA
(ICMAB). 

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), CAMPUS DE LA
UAB, SPAIN

 

RESUMEN: _Superparamagnetic iron oxide nanoparticles (SPIONs) are
already demonstrating huge potential in nanomedicine. SPIONs are
investigated as MRI contrast agents, in hyperthermia treatment, for drug
delivery, targeting therapies, biosensing and magnetic separation. The
stability of SPIONs in complex biological environments remains a
challenge and simple surface coatings to stabilize the
nanoparticlesenhancing at the same time their therapeutical effect are
currently being investigated._ 

_The talk will include a brief introduction to some synthetic approaches
used in my group.[1] _ 

_Then I will present that bovine serum albumin (BSA) can be used to
preform a protein corona on the nanoparticles surface to stabilize them
in biological media. Cellular uptake, intracellular particle
distribution and cytotoxicity of the newly acquired bio-identity of the
protein coated SPIONswill be addressed.[2]_ 

_The in vivo physiological response to the nanoparticles evaluated on
the Caenorhabditis elegans model will also be presented.[3] Finally, I
will demonstrate the application of magnetic nanoparticles and
nanocapsules to promote angiogenesis as a brain neurorepair therapy
after stroke. [4] [5]_ 

[1] Rapid synthesis of water-dispersable SPIONs by microwave assisted
route for safe labeling of 

endothelial progenitor cells, Carenza et al. _Acta-Biomaterialia_10
(2014) 3775 

[2] Bio-identityandfate of albuminpre-coated SPIONs evaluated in cells
in vitro and in vivo with the C. 

elegans model, Si-Ming Yu, et al. submitted 

[3] Protective effects of Bovine Serum Albumin on superparamagnetic iron
oxide nanoparticles evaluated 

in the nematode Caenorhabditis elegans Gonzalez-Moragas et al., ACS
Biomaterials Science & 

Engineering. 1, 11 (2015) 1129 

[4] In vitro Angiogenic Performance and in vivo Brain Targeting of
Magnetized Endothelial Progenitor Cells 

for Neurorepair Therapies, Carenza et alNanomedicine: NBM 10, 1 (2014)
225 

[5]Encapsulation of VEGF165 in magnetic PLGA nanocapsules for potential
local delivery and bioactivity 

into human brain endothelial cells, Carenza et al, J. Mater. Chem. B,
2015, 
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