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<p><strong>Estimados:</strong></p>
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<p><strong>Agradecemos la difusión del anuncio del <span class="il">seminario</span> del C<strong>iclo de Coloquios y <span class="il">Seminarios</span> que se organizan en el Instituto de Física La Plata</strong>/ <strong>Departamento de Física.</strong></strong></p>
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<div><strong>Saludos, </strong></div>
<div><strong>Atte.</strong></div>
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<div><strong>Administración IFLP</strong></div>
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<p align="center"><span style="font-size: large;"><strong><span style="text-decoration: underline;">SEMINARIOS DEL IFLP y DEL DEPARTAMENTO</span></strong></span></p>
<p align="center"><span style="font-size: large;"><strong><span style="text-decoration: underline;">MARTES 10 DE MAYO a las 11hs.</span></strong></span></p>
<p align="center"><span style="font-size: large;"><strong><span style="text-decoration: underline;">AULA CHICA</span></strong></span></p>
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<p style="text-align: justify;"><br /> <strong><span style="text-decoration: underline;">TÍTULO:</span></strong><strong> </strong><strong>Bio-identity of protein-coated SPIONs evaluated</strong><strong> </strong><strong>in cells and </strong></p>
<p style="text-align: justify;"><strong><em>in vivov</em></strong><strong>by the <em>C. elegans </em>model</strong><strong><span style="text-decoration: underline;"></span></strong></p>
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<pre><strong><span style="text-decoration: underline;">EXPONE</span></strong><strong>:</strong><strong> </strong><strong>Anna Roig. Institut de Ciència de Materials de Barcelona (ICMAB). </strong></pre>
<pre><strong>Consejo Superior de Investigaciones Científicas (CSIC), Campus de la UAB, SPAIN</strong></pre>
<pre><strong> </strong></pre>
<p style="text-align: justify;"><strong><span style="text-decoration: underline;">RESUMEN:</span></strong> <em>Superparamagnetic iron oxide nanoparticles (SPIONs) are already demonstrating huge potential in nanomedicine. SPIONs are investigated as MRI contrast agents, in hyperthermia treatment, for drug delivery, targeting therapies, biosensing and magnetic separation. The stability of SPIONs in complex biological environments remains a challenge and simple surface coatings to stabilize the nanoparticlesenhancing at the same time their therapeutical effect are currently being investigated.</em></p>
<p style="text-align: justify;"><em>The talk will include a brief introduction to some synthetic approaches used in my group.[1] </em></p>
<p style="text-align: justify;"><em>Then I will present that bovine serum albumin (BSA) can be used to preform a protein corona on the nanoparticles surface to stabilize them in biological media. Cellular uptake, intracellular particle distribution and cytotoxicity of the newly acquired bio-identity of the protein coated SPIONswill be addressed.[2]</em></p>
<p style="text-align: justify;"><em>The in vivo physiological response to the nanoparticles evaluated on the Caenorhabditis elegans model will also be presented.[3] Finally, I will demonstrate the application of magnetic nanoparticles and nanocapsules to promote angiogenesis as a brain neurorepair therapy after stroke. [4] [5]</em></p>
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<p style="text-align: justify;"><span style="font-size: xx-small;">[1] Rapid synthesis of water-dispersable SPIONs by microwave assisted route for safe labeling of</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">endothelial progenitor cells, Carenza et al. <em>Acta-Biomaterialia</em>10 (2014) 3775</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">[2] Bio-identityandfate of albuminpre-coated SPIONs evaluated in cells in vitro and in vivo with the C.</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">elegans model, Si-Ming Yu, et al. submitted</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">[3] Protective effects of Bovine Serum Albumin on superparamagnetic iron oxide nanoparticles evaluated</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">in the nematode Caenorhabditis elegans Gonzalez-Moragas et al., ACS Biomaterials Science &</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">Engineering. 1, 11 (2015) 1129</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">[4] In vitro Angiogenic Performance and in vivo Brain Targeting of Magnetized Endothelial Progenitor Cells</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">for Neurorepair Therapies, Carenza et alNanomedicine: NBM 10, 1 (2014) 225</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">[5]Encapsulation of VEGF165 in magnetic PLGA nanocapsules for potential local delivery and bioactivity</span></p>
<p style="text-align: justify;"><span style="font-size: xx-small;">into human brain endothelial cells, Carenza et al, J. Mater. Chem. B, 2015,</span></p>
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