[Alumnos] Fwd: Open SysBio Journal Club Friday 27/09/19 13:30 h

[Secretaria de Física]

-------- Mensaje original -------- 

 		ASUNTO:
 		Open SysBio Journal Club Friday 27/09/19 13:30 h

 		FECHA:
 		2019-09-23 15:29

 		REMITENTE:
 		Osvaldo Chara <ochara en gmail.com>

 		DESTINATARIO:
 		secre2 en fisica.unlp.edu.ar

Hola, queria solicitarles si pueden divulgar esta actividad destinada a
estudiantes de Fisica y Fisica medica. 
Gracias! 

Osvaldo 

--

We invite you to our next SYSBIO OPEN JOURNAL CLUB, to be held on FRIDAY
27/09/19 from 13:30 TO 15:00 H. 

We will discuss the following preprint: 

'Distinct modes of cell competition are governed by entropic and
energetic properties of mixed cell populations'  
Daniel Gradeci, Anna Bove, Alan R. Lowe, Shiladitya Banerjee, Guillaume
Charras. BioRxive. https://doi.org/10.1101/729731  

ABSTRACT: How cells with different genetic makeups compete in tissues is
an outstanding question in developmental biology and cancer research.
Studies in recent years have revealed two fundamental mechanisms of cell
competition, driven by short-range biochemical signalling or by
long-range mechanical stresses within the tissue. In both scenarios, the
outcome of cell competition has generally been characterised using
population-scale metrics. However, the underlying strategies for
competitive interactions at the single-cell level remain elusive. Here,
we develop a cell-based computational model for competition assays
informed by high-throughput timelapse imaging experiments. By
integrating physical cell interactions with cellular automata rules for
proliferation and apoptosis, we find that the emergent modes of cell
competition are determined by a trade-off between entropic and energetic
properties of the mixed tissue. While biochemical competition is
strongly sensitive to local tissue organisation, mechanical competition
is largely driven by the difference in homeostatic pressures of the two
competing cell types. These findings suggest that competitive cell
interactions arise when the local tissue free energy is high, and
proceed until free energy is minimised. 

Speaker: Natalia G. Lavalle 
Chairperson: Osvaldo Chara 

You can find the article in this link: https://doi.org/10.1101/729731 

We will meet at the Institute of Physics of Liquids and Biological
Systems (IFLYSIB), CONICET and University of La Plata (UNLP), 59th
street, 789 (between 10 and 11), Seminar room. Friday 27/09, at 13:30
pm. 

See you all there!  

 Osvaldo

-- 

Osvaldo Chara, PhD, MSc, Group Leader
*Systems Biology Group (SYS_BIO_), Instituto de Física de Líquidos y
Sistemas Biológicos (IFLYSIB),
 CONICET and University of La Plata, La Plata, Argentina.
*Center for Information Services and High Performance Computing (ZIH),
 Technische Universität Dresden,
 D-01062 Dresden, Germany.
web: http://www.sysbioiflysib.wordpress.com/
e-mail: ochara en iflysib.unlp.edu.ar, osvaldo.chara en tu-dresden.de
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