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<p>-------- Mensaje original --------</p>
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<th align="right" valign="baseline" nowrap="nowrap">Asunto:</th>
<td>Open SysBio Journal Club Friday 27/09/19 13:30 h</td>
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<th align="right" valign="baseline" nowrap="nowrap">Fecha:</th>
<td>2019-09-23 15:29</td>
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<th align="right" valign="baseline" nowrap="nowrap">Remitente:</th>
<td>Osvaldo Chara <ochara@gmail.com></td>
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<th align="right" valign="baseline" nowrap="nowrap">Destinatario:</th>
<td>secre2@fisica.unlp.edu.ar</td>
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<div dir="ltr">Hola, queria solicitarles si pueden divulgar esta actividad destinada a estudiantes de Fisica y Fisica medica.</div>
<div>Gracias! </div>
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<div>Osvaldo</div>
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<div style="font-family: 'Helvetica Neue',Helvetica,Arial,sans-serif; font-size: 16px;"><span style="font-size: small; color: #26282a; font-family: Helvetica,Arial,sans-serif;">We invite you to our next </span><strong style="font-size: small; color: #26282a; font-family: Helvetica,Arial,sans-serif;">SysBio Open <span><span><span>Journal</span></span></span> <span><span><span>Club</span></span></span></strong><span style="font-size: small; color: #26282a; font-family: Helvetica,Arial,sans-serif;">, to be held on <strong>Friday</strong></span><strong style="font-size: small; color: #26282a; font-family: Helvetica,Arial,sans-serif;"> 27/09/19 </strong><span style="font-size: small; color: #26282a; font-family: Helvetica,Arial,sans-serif;">from </span><strong style="font-size: small; color: #26282a; font-family: Helvetica,Arial,sans-serif;">13:30 to 15:00 <span style="font-size: small;">h.</span></strong></div>
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<div style="color: #26282a; font-family: Helvetica,Arial,sans-serif; font-size: 13px;"><span style="font-size: small;">We will discuss the following preprint:</span></div>
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<div style="color: #26282a; font-family: Helvetica,Arial,sans-serif; font-size: 13px;"><strong><span style="font-size: small;">'</span></strong>Distinct modes of cell competition are governed by entropic and energetic properties of mixed cell populations<strong><span style="font-family: Arial,Helvetica,sans-serif; font-size: small; color: #222222;">' </span></strong></div>
<div style="color: #26282a; font-family: Helvetica,Arial,sans-serif; font-size: 13px;">Daniel Gradeci, Anna Bove, Alan R. Lowe, Shiladitya Banerjee, Guillaume Charras. BioRxive. <span><a href="https://doi.org/10.1101/729731">https://doi.org/10.1101/729731</a></span> <span style="font-family: Arial,Helvetica,sans-serif; font-size: small; color: #222222;"></span></div>
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<div style="color: #26282a; font-family: Helvetica,Arial,sans-serif; font-size: 13px;"><strong>Abstract</strong>: How cells with different genetic makeups compete in tissues is an outstanding question in developmental biology and cancer research. Studies in recent years have revealed two fundamental mechanisms of cell competition, driven by short-range biochemical signalling or by long-range mechanical stresses within the tissue. In both scenarios, the outcome of cell competition has generally been characterised using population-scale metrics. However, the underlying strategies for competitive interactions at the single-cell level remain elusive. Here, we develop a cell-based computational model for competition assays informed by high-throughput timelapse imaging experiments. By integrating physical cell interactions with cellular automata rules for proliferation and apoptosis, we find that the emergent modes of cell competition are determined by a trade-off between entropic and energetic properties of the mixed tissue. While biochemical competition is strongly sensitive to local tissue organisation, mechanical competition is largely driven by the difference in homeostatic pressures of the two competing cell types. These findings suggest that competitive cell interactions arise when the local tissue free energy is high, and proceed until free energy is minimised.</div>
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<div style="color: #26282a; font-family: Helvetica,Arial,sans-serif; font-size: 13px;"><u>Speaker</u>: Natalia G. Lavalle</div>
<div style="color: #26282a; font-family: Helvetica,Arial,sans-serif; font-size: 13px;"><u>Chairperson</u>: Osvaldo Chara</div>
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<div><span style="font-size: small;">You can find the article in this link: <a href="https://doi.org/10.1101/729731">https://doi.org/10.1101/729731</a></span></div>
<div><span style="font-size: small;"> </span></div>
<div><span style="font-size: small;">We will meet at the Institute of Physics of Liquids and Biological Systems (IFLYSIB), CONICET and University of La Plata (UNLP), 59th street, 789 (between 10 and 11), Seminar room. Friday 27/09, at 13:30 pm.</span></div>
<div><span style="font-size: small;"> </span></div>
<div><span style="font-size: small;">See you all there!</span> <span style="font-size: small;"><br /></span></div>
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Osvaldo<br clear="all" />
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<div dir="ltr">Osvaldo Chara, PhD, MSc, Group Leader<br /><strong>*</strong>Systems Biology Group (<strong><span style="color: #0000ff;">Sys</span></strong><span style="color: #6aa84f;"><em><strong>Bio</strong></em></span>), Instituto de Física de Líquidos y Sistemas Biológicos (<strong>IFLySiB</strong>),<br /> <strong>CONICET</strong> and University of La Plata, La Plata, Argentina.<br /><strong>*</strong>Center for Information Services and High Performance Computing (<strong>ZIH</strong>),<br /> Technische Universität Dresden,<br /> D-01062 Dresden, Germany.<br /><u>web</u>: <a href="http://www.sysbioiflysib.wordpress.com/">http://www.sysbioiflysib.wordpress.com/</a><br /><u>e-mail</u>: <span style="color: #0000ff;"><a href="mailto:ochara@iflysib.unlp.edu.ar">ochara@iflysib.unlp.edu.ar</a></span>, <span style="color: #0000ff;"><a href="mailto:osvaldo.chara@tu-dresden.de">osvaldo.chara@tu-dresden.de</a></span></div>
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