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<td>CHARLA IFLYSIB - Viernes 25/10, 10.30hs - "Tig1, a new player in the establishment of the proximo-distal axis during salamander limb regeneration"</td>
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<td>2019-10-18 16:32</td>
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<td>Charlas Iflysib <charlas.iflysib@gmail.com></td>
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<th align="right" valign="baseline" nowrap="nowrap">Destinatario:</th>
<td>Charlas Iflysib <charlas-iflysib@googlegroups.com>, academic@fcaglp.unlp.edu.ar, fcnym@museo.fcnym.unlp.edu.ar, info@ciop.unlp.edu.ar, internet@biol.unlp.edu.ar, scyt@frlp.utn.edu.ar, Asistentes de Secretaria de Fisica <secre2@fisica.unlp.edu.ar>, secre@biol.unlp.edu.ar, secre@mate.unlp.edu.ar, secretaria@inifta.unlp.edu.ar, secre@quimica.unlp.edu.ar</td>
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<div dir="ltr"><strong style="color: #500050;">Los esperamos con café 15 minutos antes de la charla en el lobby del instituto</strong><span style="color: #500050;">.</span> </div>
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<div dir="ltr" style="text-align: center;"><strong style="color: #6aa84f;"><span style="font-size: large;">Charla IFLYSIB</span></strong></div>
<div dir="ltr" style="text-align: center;"><strong style="color: #6aa84f;"><span style="font-size: large;">Viernes 25/10, 10:30hs.</span></strong></div>
<div dir="ltr" style="text-align: center;"><strong style="color: #6aa84f;"><span style="font-size: small;">Lugar: IFLySiB (59 #789, La Plata)</span></strong></div>
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<div><strong>Título: </strong><strong style="color: #1d2228; font-family: 'Helvetica Neue',Helvetica,Arial,sans-serif; font-size: 13px;">Tig1, a new player in the establishment of the proximo-distal axis during salamander limb regeneration</strong><strong><em> </em></strong></div>
<div><strong>Expositora: Catarina Oliveira </strong></div>
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<div style="font-family: 'Helvetica Neue',Helvetica,Arial,sans-serif; font-size: 13px; color: #000000;">Yun Lab - Regeneration of complex structures in adult vertebrates. CRTD - DFG Center for Regenerative Therapies Dresden. Dresden, Germany.</div>
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<div><strong>Resumen: </strong></div>
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<p dir="ltr" style="line-height: 1.2; text-align: justify; margin-top: 0pt; margin-bottom: 0pt;">Salamanders have the remarkable ability to regenerate their entire limbs throughout life. Limb regeneration is an accurate process which gives rise exclusively to the missing structures and in the correct proportions, irrespective of the amputation level. This suggests that cells in the stump have a memory of their position within the limb, a property termed 'positional identity'. At present, very little is known about how positional identity is encoded at the molecular level and how it interplays with tissue growth. Through a single cell RNAseq approach we recently identified the Tig1 tumour suppressor as a potential determinant of proximal identity. Tig1 exhibits graded expression along the proximodistal axis, is regulated by the proximalising factor retinoic acid, and is able to change the fate of distal cells to more proximal locations along the regenerating limb. In this talk, we will discuss evidence supporting the role of Tig1 as a new determinant of proximodistal identity and present molecular data that help to shed light on its functions during limb regeneration.</p>
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<div><span style="font-size: large;"><span style="font-family: arial;"><strong>Comisión ChIFLy</strong></span></span></div>
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