[Todos] Fwd: Next Open Sysbio Journal Club (Tomorrow!)

[Secretaria de Física]

-------- Mensaje original -------- 

 		ASUNTO:
 		Next Open Sysbio Journal Club (Tomorrow!)

 		FECHA:
 		2019-09-30 17:23

 		REMITENTE:
 		Osvaldo Chara <ochara en gmail.com>

 		DESTINATARIO:
 		Pedrojose Didone <pedrojosedidone en yahoo.com.ar>, Enzo Aman
<enzoaman98 en gmail.com>, Josefina Medina <josefinaemedina en gmail.com>,
Sebastián Carruitero <seba.carruitero en gmail.com>, Martin Lagares
<martinlagares95 en gmail.com>, valentin.attarantato en gmail.com,
aguscaputounlp en gmail.com, secre2 en fisica.unlp.edu.ar

We invite you to our next SYSBIO OPEN JOURNAL CLUB, to be held on
Tuesday 01/10/19 from 15:30 TO 17:00 H. 

We will discuss the following preprint: 

' Genome-scale single-cell mechanical phenotyping reveals
disease-related genes involved in mitotic rounding '  
Yusuke Toyoda , Cedric J. Cattin, Martin P. Stewart , Ina Poser , Mirko
Theis, Teymuras V. Kurzchalia , Frank Buchholz, Anthony A. Hyman &
Daniel J. Müller .  
 NATURE COMMUNICATIONS | 8: 1266 |DOI: 10.1038/s41467-017-01147-6 |
www.nature.com/naturecommunications [1] 

ABSTRACT:To divide, most animal cells drastically change shape and round
up against extracellular confinement. Mitotic cells facilitate this
process by generating intracellular pressure, which the contractile
actomyosin cortex directs into shape. Here, we introduce a genome-scale
microcantilever- and RNAi-based approach to phenotype the contribution
of > 1000 genes to the rounding of single mitotic cells against
confinement. Our screen analyzes the rounding force, pressure and volume
of mitotic cells and localizes selected proteins. We identify 49 genes
relevant for mitotic rounding, a large portion of which have not
previously been linked to mitosis or cell mechanics. Among these,
depleting the endoplasmic reticulum-localized protein FAM134A impairs
mitotic progression by affecting metaphase plate alignment and pressure
generation by delocalizing cortical myosin II. Furthermore, silencing
the DJ-1 gene uncovers a link between mitochondria-associated
Parkinson's disease and mitotic pressure. We conclude that mechanical
phenotyping is a powerful approach to study the mechanisms governing
cell shape. 

Speaker: Emanuel Cura Costa 
Chairperson: Natalia Lavalle 

You can find the article in this
link:https://www.nature.com/articles/s41467-017-01147-6.pdf 

We will meet at the Institute of Physics of Liquids and Biological
Systems (IFLYSIB), CONICET and University of La Plata (UNLP), 59th
street, 789 (between 10 and 11), Seminar room. Tuesday  01/10, at 15:30
pm. 

See you all there!  

 		 [2]
 		Libre de virus. www.avast.com [2]

 

Links:
------
[1] http://www.nature.com/naturecommunications
[2]
https://www.avast.com/sig-email?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail
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