[Todos] Fwd: Seminarios del IFLP/Departamento de Física

Lun Mar 12 13:25:02 -03 2018

-------- Mensaje original -------- 

 		ASUNTO:
 		Seminarios del IFLP/Departamento de Física

 		FECHA:
 		2018-03-12 13:23

 		REMITENTE:
 		Maria Virginia Manias <virmanias en gmail.com>

 		DESTINATARIO:
 		Secretaria del Dpto.de Física <secre2 en fisica.unlp.edu.ar>,
secre en biol.unlp.edu.ar, secre en mate.unlp.edu.ar,
secretaria en inifta.unlp.edu.ar, iflysib en iflysib.unlp.edu.ar,
fcnym en museo.fcnym.unlp.edu.ar, info en ciop.unlp.edu.ar,
academic en fcaglp.unlp.edu.ar, todos en fisica.unlp.edu.ar

Estimados,

Les agradezco la difusión del anuncio de los próximos seminarios del
Ciclo de Coloquios y Seminarios que se organizan el Instituto de Física
La Plata y el Departamento de Física.  

Saludos cordiales,
Virginia Manías - Secretaria Científica del IFLP 
SEMINARIOS  DEL IFLP Y DEL DEPARTAMENTO 

AULA CHICA 

EXPOSITOR: PROF. SILVIO DUTZ 

_TECHNISCHE UNIVERSITÄT DE ILMENAU, ALEMANIA_ 

MARTES 13 DE MARZO – 11HS 

TÍTULO: "MAGNETIC NANOPARTICLES: MEDICAL APPLICATIONS" 

RESUMEN: The application of magnetic nanoparticles (MNP) in a biomedical
context is a rapidly developing field. MNPs suspended in aqueous liquids
can be introduced into the blood circulation or the tissue of a patient
allowing for the utilization of magnetic effects such as magnetic
losses, magnetic forces, and localized sources of magnetic fields for
the detection or treatment of several diseases. For example, magnetic
particle hyperthermia uses the magnetization reversal losses of such
particles in an alternating magnetic field to achieve a local heating of
the tissue in order to treat tumors by thermal damage of tumor tissue.
Magnetic drug targeting take advantage of magnetic forces acting on drug
loaded MNP in an external static field gradient to accumulate them in
the tissue areas to be treated by the drugs. This method is also
promising for tumor therapy which was investigated in animal
experiments. In magnetic particle imaging (MPI) the local nonlinear
magnetic response of MNP in the tissue to an external field is used to
construct a 3-dimensional image of the particle distribution which can
be related to structural features of the tissue when using the MNP as
tracer materials. Beside these prominent applications of MNP, other
possible use of MNP in medicine will be shown. 

JUEVES 15 DE MARZO – 11HS 

TÍTULO: "MAGNETIC NANOPARTICLES: CURRENT RESEARCH" 

RESUMEN: In this presentation, current results of two research projects
of Prof. Dutz (TU Ilmenau/Germany) on the development of magnetic
nanoparticles for medical application will be presented. 

The first part is on the development of cobalt doped iron oxides. For
tuning of the magnetic properties, the Fe2+ ions of magnetite were
substituted by Co2+ step by step, which results in a Co doped inverse
spinel with adjustable Fe2+ substitution degree. For dry particles, a
strong correlation between Co content and resulting Hc and Mr/Ms was
found. For increasing Co concentrations from 0 to 8.6% only a slight
increase of Hc was found, but from 12 to 25% a strong linear increase
results. Within this linear range of dependency, the magnetic properties
of the particles, especially Hc, can be tuned easily by changing Co
content of the particles. A specific correlation of heating power of
gel-immobilized particles with the Co content will be presented and best
samples show very good performance for application in hyperthermia. 

The second part is on the development of highly biocompatible protein
coatings for MNP. For this, cytotoxic polyethylenimine (PEI)-coated
nanoparticles were incubated in fetal calf serum (FCS) to form a
so-called protein corona on the surface of the particles. The acute
cytotoxic effect of incubated particles was tested for human brain
microvascular endothelial cells (HBMEC) by the CellTiter Glo(tm) Cell
Viability Assay and for long-term viability up to 96 h by real time cell
analysis (RTCA). Interactions of coated MNP and serum incubated MNP with
HBMEC were investigated by means of flow cytometry and laser scanning
microscopy of fluorochrome-labelled particles. Cell toxicity assays
revealed no cytotoxic effect of PEI coated MNP, which were covered by a
protein corona. Long-term RTCA showed that the protein corona might mask
the cytotoxic effect of PEI. Flow cytometry indicate that FCS coating
reduces the particle-cell interaction of cytotoxic PEI coated MNP 

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SEMINARIOS  DEL IFLP Y DEL DEPARTAMENTO 

AULA CHICA 

EXPOSITOR: PROF. ORESTE PIRO 

_DEPARTAMENTO DE FÍSICA, UNIVERSITAT DE LES ILLES BALEARS, ESPAÑA  _ 

JUEVES 15 DE MARZO – 15HS 

TÍTULO: "Fases geométricas en el estómago (the 'belly" phase)¨

Resumen: Se expondrán ciertas correlaciones entre los aspectos dinámicos
y geométricos del transporte y mezcla de fluidos a bajos números de
Reynolds, en recipientes cuyas paredes deformables ejecutan un ciclo en
el espacio de las formas. Un ejemplo de estos es el estómago, cuyas
paredes están sujetas a ciclos de peristalsis responsables tanto del
transporte como de la mezcla de los alimentos y líquidos gástricos para
formar el quimo. Se especula que el correcto funcionamiento del
estómago, como mezclador, depende de la capacidad de inducir "fases
geométricas" por medio de estos ciclos peristálticos. 

 		 [1]
 		Libre de virus. www.avg.com [1]

Links:
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[1]
http://www.avg.com/email-signature?utm_medium=email&utm_source=link&utm_campaign=sig-email&utm_content=webmail
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