[Todos] Fwd: seminarios profesor Silvio Dutz Ilmenau: Magnetic NPs

Sab Mar 10 21:39:34 -03 2018

-------- Mensaje original -------- 

 		ASUNTO:
 		seminarios profesor Silvio Dutz Ilmenau: Magnetic NPs

 		FECHA:
 		2018-03-10 18:41

 		REMITENTE:
 		Francisco Sánchez <sanchez en fisica.unlp.edu.ar>

 		DESTINATARIO:
 		Secretaria del Dpto.de Física <secre2 en fisica.unlp.edu.ar>

Hola Cecilia, Alejandro, ¿podrían difundir esta invitación? 

Muchas gracias 

Quique

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Hola a todos 

Entre el lunes 12 y viernes 16 de marzo, el Prof. Silvio Dutz, de la
Universidad de Ilmenau, estará de visita en el IFLP (La Plata). Silvio
integró el grupo de Rudolf Hergt un reconocido investigador, pionero en
el estudio de la capacidad de las NPs magnéticas como nanocalefactores
aprovechando su capacidad de transducir energía electromagnética en
calor, y de su aplicación en una terapia oncológica por hipertermia
magnética. 
Durante su visita Silvio dará un breve curso consistente de 4 seminarios
que se realizarán en el Aula Chica del Departamento:  

S1: MAGNETIC NANOPARTICLES: PREPARATION AND MAGNETIC PROPERTIES, lunes
12/03 de 14 a 15 hs 

S2: MAGNETIC NANOPARTICLES: MEDICAL APPLICATIONS, martes 13/03 de 11 a
12 a 12 hs (coincide con seminario del Departamento e IFLP) 

The application of magnetic nanoparticles (MNP) in a biomedical context
is a rapidly developing field. MNPs suspended in aqueous liquids can be
introduced into the blood circulation or the tissue of a patient
allowing for the utilization of magnetic effects such as magnetic
losses, magnetic forces, and localized sources of magnetic fields for
the detection or treatment of several diseases. For example, magnetic
particle hyperthermia uses the magnetization reversal losses of such
particles in an alternating magnetic field to achieve a local heating of
the tissue in order to treat tumors by thermal damage of tumor tissue.
Magnetic drug targeting take advantage of magnetic forces acting on drug
loaded MNP in an external static field gradient to accumulate them in
the tissue areas to be treated by the drugs. This method is also
promising for tumor therapy which was investigated in animal
experiments. In magnetic particle imaging (MPI) the local nonlinear
magnetic response of MNP in the tissue to an external field is used to
construct a 3-dimensional image of the particle distribution which can
be related to structural features of the tissue when using the MNP as
tracer materials. Beside these prominent applications of MNP, other
possible use of MNP in medicine will be shown. 
S3: MAGNETIC NANOPARTICLES: PHYSICAL ASPECTS OF HYPERTHERMIA, miércoles
14/03 de 11 a 12 hs 

S4: MAGNETIC NANOPARTICLES: CURRENT RESEARCH, jueves 15/03 de 11 a 12 hs
 (coincide con seminario del Departamento e IFLP) 

In this presentation, current results of two research projects of Prof.
Dutz (TU Ilmenau/Germany) on the development of magnetic nanoparticles
for medical application will be presented. 

The first part is on the development of cobalt doped iron oxides. For
tuning of the magnetic properties, the Fe2+ ions of magnetite were
substituted by Co2+ step by step, which results in a Co doped inverse
spinel with adjustable Fe2+ substitution degree. For dry particles, a
strong correlation between Co content and resulting Hc and Mr/Ms was
found. For increasing Co concentrations from 0 to 8.6% only a slight
increase of Hc was found, but from 12 to 25% a strong linear increase
results. Within this linear range of dependency, the magnetic properties
of the particles, especially Hc, can be tuned easily by changing Co
content of the particles. A specific correlation of heating power of
gel-immobilized particles with the Co content will be presented and best
samples show very good performance for application in hyperthermia. 

The second part is on the development of highly biocompatible protein
coatings for MNP. For this, cytotoxic polyethylenimine (PEI)-coated
nanoparticles were incubated in fetal calf serum (FCS) to form a
so-called protein corona on the surface of the particles. The acute
cytotoxic effect of incubated particles was tested for human brain
microvascular endothelial cells (HBMEC) by the CellTiter Glo(tm) Cell
Viability Assay and for long-term viability up to 96 h by real time cell
analysis (RTCA). Interactions of coated MNP and serum incubated MNP with
HBMEC were investigated by means of flow cytometry and laser scanning
microscopy of fluorochrome-labelled particles. Cell toxicity assays
revealed no cytotoxic effect of PEI coated MNP, which were covered by a
protein corona. Long-term RTCA showed that the protein corona might mask
the cytotoxic effect of PEI. Flow cytometry indicate that FCS coating
reduces the particle-cell interaction of cytotoxic PEI coated MNP. 

Pueden interiorizarse sobre Silvio en:
https://www.tu-ilmenau.de/bmti/fachgebiete/multimodale-datenanalyse-in-der-biomedizintechnik/jun-prof-dr-ing-silvio-dutz/
[1] 

A quienes piensen asistir, les pido que en lo posible lo confirmen por
este medio. 

Saludos 
Quique 
  -- 

*************************************************************************************

 Dr. Francisco H. Sánchez
Departamento - Instituto de Física - Facultad de Ciencias Exactas
UNLP - CONICET
49 y 115 (1900) La Plata, Argentina
+54 221 424 6062 x 223
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Links:
------
[1]
https://www.tu-ilmenau.de/bmti/fachgebiete/multimodale-datenanalyse-in-der-biomedizintechnik/jun-prof-dr-ing-silvio-dutz/
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