[Todos] Fwd: [info.statphys] Biophysics post-doc in Paris

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 		Fwd: [info.statphys] Biophysics post-doc in Paris

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 		2018-06-01 08:51

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 		Mariela Portesi <mariela.portesi en gmail.com>

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---------- Forwarded message ---------
From: Claude Loverdo <info.statphys en listes.ens-lyon.fr>
Date: vie., 1 de jun. de 2018 3:18 AM
Subject: [info.statphys] Biophysics post-doc in Paris
To: <info.statphys en listes.ens-lyon.fr> 

Post-doc: Modeling vaccination/niche competition in the gut for
microbiota engineering

We are looking for a post doctoral researcher to model vaccination and
niche competition effects in the gut for microbiota engineering.
Antibiotic multi-resistant (AMR) bacteria that frequently inhabit the
intestinal tract of humans and livestock are a serious threat. Our
recent work demonstrates that intestinal antibodies, raised by
inactivated oral vaccines, enforce the targeted strain to undergo
"enchained growth", forming large clumps. During the project, a protocol
combining vaccination with introduction of a niche competitor, for
targeted drug-free removal of an individual bacterial strain from the
microbiota of mice, will be developed, and extended to domestic pigs.
Combining mathematical models and quantitative dynamic data will provide
a solid framework for subsequent large-scale trials and extension to
more diverse bacterial species and hosts.

The postdoc will analyze experimental data to extract information about
the bacterial populations dynamics. He/she will develop biophysical
models of the microbiota dynamics in the gut, integrating immune
dynamics and competition, and animal size and physiology. Beyond the
direct applications to the experiments of the project, the goal is to
gain a better understanding on how the physical conditions in the gut
interplay with the microbiota dynamics. 

The postdoc will be based in Sorbonne Université, Paris, under the
supervision of Claude Loverdo, and the work will be in close
collaboration with Emma Slack, ETH Zürich. The postdoc will be
integrated to the theory team of the Laboratoire Jean Perrin, a young
and dynamic biophysical lab, in the center of Paris. The postdoc
duration is 12+ months, start date negotiable from September 2018, with
salary according to experience. 

The candidate should have a PhD (or have it completed before the start
of the position), in physics or a related field, and a strong experience
in modeling. Moreover he/she should have a deep interest and possibly a
previous experience in biology.

If you are interested please send us a CV and a short email motivating
your interest in the position.
Claude Loverdo claude.loverdo en upmc.fr 
Emma Slack emma.slack en micro.biol.ethz.ch 

Most relevant publications: 
- K.Moor, M.Diard, M.E.Sellin, B.Felmy, S.Y.Wotzka, A.Toska, E.Bakkaren,
M.Arnoldini, F.Bansept, A.Dal Co, T.Voller, A.Minola,
B.Fernandez-Rodriguez, G.Agatic, S.Barbieri, L.Piccoli, C.Casiraghi,
D.Corti, A.Lanzavecchia, R.R.Regoes, C.Loverdo, R.Stocker, D.R.Brumley,
W-D.Hardt, E.Slack. High-avidity IgA protects the intestine by
enchaining growing bacteria. Nature 544:498--502 (2017)
- M.Diard, E.Bakkaren, J.K.Cornuault, A.Hausmann, K.Moor, M.E.Sellin,
C.Loverdo, A.Aertsen, M.Ackermann, M.De Paepe, E.Slack, W-D.Hardt.
Inflammation boosts bacteriophage transfer between Salmonella spp.
Science 355:1211--1215 (2017)
- F.Bansept, K.Schumann-Moor, M.Diard, W-D.Hardt, E.Slack, C.Loverdo, 
Enchained growth and cluster dislocation : a possible mechanism for
microbiota homeostasis, bioRxiv:298059
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