[Todos] Fwd: CHARLA IFLYSIB: Martes 27/2, 10.30hs: Studying the mechanism of DNA translocation by molecular motors in bacteria

[Asistentes de Secretaria de Fisica]

-------- Mensaje original -------- 

 		ASUNTO:
 		CHARLA IFLYSIB: Martes 27/2, 10.30hs: Studying the mechanism of DNA
translocation by molecular motors in bacteria

 		FECHA:
 		2018-02-22 18:49

 		REMITENTE:
 		Charlas Iflysib <charlas.iflysib en gmail.com>

 		DESTINATARIO:
 		Charlas Iflysib <charlas-iflysib en googlegroups.com>

 		COPIA:
 		academic en fcaglp.unlp.edu.ar, fcnym en museo.fcnym.unlp.edu.ar,
info en ciop.unlp.edu.ar, internet en biol.unlp.edu.ar, scyt en frlp.utn.edu.ar,
secre2 en fisica.unlp.edu.ar, secre en biol.unlp.edu.ar,
secre en mate.unlp.edu.ar, secretaria en inifta.unlp.edu.ar

El próximo Martes 27/2 daremos inicio a la temporada 2018 de las Charlas
de IFLYSIB. 
LOS ESPERAMOS CON CAFÉ 15 MINUTOS ANTES DE LA CHARLA EN EL LOBBY DEL
INSTITUTO.

CHARLAS DEL IFLYSIB

DÍA Y HORARIO: MARTES 27/2, 10.30HS.

LUGAR: IFLySiB (59 #789, La Plata) 
TÍTULO: _STUDYING THE MECHANISM OF DNA TRANSLOCATION BY MOLECULAR MOTORS
IN BACTERIA_ 

EXPOSITOR: _DIEGO CATTONI_
Centre de Biochimie Structurale
DNA segregation and Remodeling Team
INSERM/CNRS/Université de Montpellier

 RESUMEN: 
SpoIIIE is a membrane-anchored, ATP-fuelled, directional motor
responsible for chromosomal segregation in bacteria. Directionality in
these motors is governed by interactions between specialized
sequence-recognition modules and highly skewed chromosomal sequences. In
this presentation I will describe our efforts in trying to understand
the principles defining and regulating the direction of translocation of
DNA in sporulating Bacillus subtilis by using a combination of in vivo,
in vitro and in silico approaches. We have been able to show that
hexamers of the motor do not require the presence of specific sequences
to assemble but that their presence fine tunes the catalytic activity of
the motor and thus its direction of translocation. In turn the
communication between the motor activity regulation and membrane domains
of the enzyme preserves the open pore through with DNA is transported
between membranes. Additionally, I will briefly describe the new
approaches we are currently implementing in our laboratory to study
chromosome organization and segregation both in prokaryotes and
eukaryotes.

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