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<th align="right" valign="baseline" nowrap="nowrap">Asunto:</th>
<td>charla divulgación difundir</td>
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<th align="right" valign="baseline" nowrap="nowrap">Fecha:</th>
<td>2019-09-30 13:20</td>
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<th align="right" valign="baseline" nowrap="nowrap">Remitente:</th>
<td>natalia lavalle <natylavalle1@hotmail.com></td>
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<th align="right" valign="baseline" nowrap="nowrap">Destinatario:</th>
<td>Secretaria de Física <secre2@fisica.unlp.edu.ar></td>
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<div style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: #000000;"><br />Hola Alejandro podrás reenviar este mail a los alumnos de Física ? muchas gracias .</div>
<div style="font-family: Calibri, Helvetica, sans-serif; font-size: 12pt; color: #000000;">Atte. Natalia</div>
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<div style="color: #222222; background-color: #ffffff; font-family: 'Helvetica Neue', Helvetica, Arial, sans-serif;"><span style="font-size: small; color: #26282a; font-family: Helvetica, Arial, sans-serif;">We invite you to our next </span><strong style="font-size: small; color: #26282a; font-family: Helvetica, Arial, sans-serif;">SysBio Open Journal Club</strong><span style="font-size: small; color: #26282a; font-family: Helvetica, Arial, sans-serif;">, to be held on Tuesday 01</span><strong style="font-size: small; color: #26282a; font-family: Helvetica, Arial, sans-serif;">/10/19 </strong><span style="font-size: small; color: #26282a; font-family: Helvetica, Arial, sans-serif;">from </span><strong style="font-size: small; color: #26282a; font-family: Helvetica, Arial, sans-serif;">15:30 to 17:00 <span style="font-size: small;">h.</span></strong></div>
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<div style="color: #26282a; font-family: Helvetica, Arial, sans-serif; font-size: 13px;"><span style="font-size: small;">We will discuss the following preprint:</span></div>
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<div style="color: #26282a; font-family: Helvetica, Arial, sans-serif; font-size: 13px;"><strong><span style="font-size: small;">'</span></strong><span> </span>Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding<span> </span><strong><span style="font-family: Arial, Helvetica, sans-serif; font-size: small; color: #222222;">' </span></strong></div>
<div style="color: #26282a; font-family: Helvetica, Arial, sans-serif; font-size: 13px;">Yusuke Toyoda , Cedric J. Cattin, Martin P. Stewart , Ina Poser , Mirko Theis, Teymuras V. Kurzchalia , Frank Buchholz, Anthony A. Hyman & Daniel J. Müller . </div>
<div style="color: #26282a; font-family: Helvetica, Arial, sans-serif; font-size: 13px;"> NATURE COMMUNICATIONS | 8: 1266 |DOI: 10.1038/s41467-017-01147-6 |<span> </span><a style="color: #1155cc;" href="http://www.nature.com/naturecommunications">www.nature.com/<wbr />naturecommunications</a></div>
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<div style="color: #26282a; font-family: Helvetica, Arial, sans-serif; font-size: 13px;"><strong>Abstract</strong>:<span style="font-family: Arial, Helvetica, sans-serif; font-size: small; color: #222222;">To divide, most animal cells drastically change shape and round up against extracellular confinement. Mitotic cells facilitate this process by generating intracellular pressure, which the contractile actomyosin cortex directs into shape. Here, we introduce a genome-scale microcantilever- and RNAi-based approach to phenotype the contribution of > 1000 genes to the rounding of single mitotic cells against confinement. Our screen analyzes the rounding force, pressure and volume of mitotic cells and localizes selected proteins. We identify 49 genes relevant for mitotic rounding, a large portion of which have not previously been linked to mitosis or cell mechanics. Among these, depleting the endoplasmic reticulum-localized protein FAM134A impairs mitotic progression by affecting metaphase plate alignment and pressure generation by delocalizing cortical myosin II. Furthermore, silencing the DJ-1 gene uncovers a link between mitochondria-associated Parkinson's disease and mitotic pressure. We conclude that mechanical phenotyping is a powerful approach to study the mechanisms governing cell shape.</span></div>
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<div style="color: #26282a; font-family: Helvetica, Arial, sans-serif; font-size: 13px;"><u>Speaker</u>: Emanuel Cura Costa</div>
<div style="color: #26282a; font-family: Helvetica, Arial, sans-serif; font-size: 13px;"><u>Chairperson</u>: Natalia Lavalle</div>
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<div><span style="font-size: small;">You can find the article in this link:</span><a style="color: #1155cc;" href="https://www.nature.com/articles/s41467-017-01147-6.pdf">https://www.nature.com/<wbr />articles/s41467-017-01147-6.<wbr />pdf</a></div>
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<div><span style="font-size: small;">We will meet at the Institute of Physics of Liquids and Biological Systems (IFLYSIB), CONICET and University of La Plata (UNLP), 59th street, 789 (between 10 and 11), Seminar room. Tuesday 01/10, at 15:30 pm.</span></div>
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<div><span style="font-size: small;">See you all there!</span> </div>
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